A Plan of Safe Care must be developed for all infants affected by prenatal drug or fetal alcohol exposure in order to support mothers, infants and their families per federal [1] and state requirements. A Plan of Safe Care is a critical tool - not only for every infant born exposed to prenatal substance exposure but for all mothers and their infants. Developed collaboratively with the mother, a Plan of Safe Care coordinates existing supports and referrals to new services to help infants and families stay supported and connected when they leave the hospital.